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Thread: Fancy getting 30 years younger?

  1. #1
    Really Bored oldboy's Avatar
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    Default Fancy getting 30 years younger?

    Forever young - Is this breakthrough the end of the ageing process? | City A.M.

    crappy report - wouldn't mind seeing a proper article
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    Really Bored KungFooBob's Avatar
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    Default Re: Fancy getting 30 years younger?

    Not really, I don't fancy being 5 again.

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    Should Get Out More KorkyKat's Avatar
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    Default Re: Fancy getting 30 years younger?

    It was discussed this morning on Today. As usual a scientist dissed the idea - as they do.

    All you have to do is heed the daily tripe spouted and you will go back to the womb.

    Eating nuts each day will save you from terrible diseases

    Eat more chocolate to reduce your health risks

    Eat an apple a day and live ten years longer than pear eaters.

    Eat porridge and live five years longer

    Drink a shot of whisky each night and save five years off your life

    Piss slanted and save your bladder

    Zzzzzzzzzzzz!
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    Should Get Out More Splat's Avatar
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    Default Re: Fancy getting 30 years younger?

    No, I was insufferable when I was young.
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    Default Re: Fancy getting 30 years younger?

    nicotinamide eh?

    Who said smoking was bad for you?

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    Default Re: Fancy getting 30 years younger?

    That would make me 7 which would mean I would be REALLY looking forward to Christmas. Where do I sign up?

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    Really Bored oldboy's Avatar
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    Default Re: Fancy getting 30 years younger?

    Quote Originally Posted by Splat View Post
    No, I was insufferable when I was young.
    I'm glad you changed.
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    Should Get Out More Greenman's Avatar
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    Default Re: Fancy getting 30 years younger?

    <BM mode on>

    I don't know, but 'Forever Young' is the name of a new track i'm working on...

    <BM mode off>

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    Really Bored oldboy's Avatar
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    Default Re: Fancy getting 30 years younger?

    Quote Originally Posted by Jollyjack View Post
    nicotinamide eh?

    Who said smoking was bad for you?
    I think there was a Woody Allen film where he was frozen and woke up in the future. Everyone is smoking because they had since discovered it was good for you.
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    Should Get Out More Splat's Avatar
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    Default Re: Fancy getting 30 years younger?

    Quote Originally Posted by oldboy View Post
    I'm glad you changed.
    I like people who are easily pleased. You're back on my Christmas card list. Oh...
    Last edited by Splat; 20-12-13 at 16:09.
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    Should Get Out More moth's Avatar
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    Default Re: Fancy getting 30 years younger?

    Quote Originally Posted by Greenman View Post
    <BM mode on>

    I don't know, but 'Forever Young' is the name of a new track i'm working on...

    <BM mode off>

    Oh dear



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    Default Re: Fancy getting 30 years younger?

    A married couple in their early 60s was celebrating their 40th wedding anniversary in a quiet, romantic little restaurant.
    Suddenly, a tiny yet beautiful fairy appeared on their table. She said, 'For being such an exemplary married couple and for being loving to each other for all this time, I will grant you each a wish.'

    The wife answered, 'Oh, I want to travel around the world with my darling husband
    The fairy waved her magic wand and - poof! - two tickets for the Queen Mary II appeared in her hands.

    The husband thought for a moment: 'Well, this is all very romantic, but an opportunity like this will never come again. I'm sorry my love, but my wish is to have a wife 30 years younger than me.
    The wife, and the fairy, were deeply disappointed, but a wish is a wish.

    So the fairy waved her magic wand and poof!...the husband became 92 years old.

    The moral of this story:
    Men who are ungrateful bastards should remember fairies are female.....

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    Default Re: Fancy getting 30 years younger?

    It would be better if they concentrated in controlling the world population rather than trying to make it so we all live longer and longer and longer.

    The uncontrolled plague of mankind will be its downfall.

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    Default Re: Fancy getting 30 years younger?

    Quote Originally Posted by Wreckless Rat View Post
    It would be better if they concentrated in controlling the world population rather than trying to make it so we all live longer and longer and longer.

    The uncontrolled plague of mankind will be its downfall.
    Bloody hell you even get out of bed early on a Saturday just to be miserable.
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    Default Re: Fancy getting 30 years younger?

    Beat me to it as I was going to post a thread with "Flowers For Algernon" as the title, anyway the report was in New Scientist.

    " Turning back time: ageing reversed in mice

    17:52 19 December 2013 by Laasya Samhita
    For similar stories, visit the Cancer Topic Guide

    Imagine if we could turn back time. A team that has identified a new way in which cells age has also reversed the process in old mice whose bodies appear younger in several ways. The discovery has implications for understanding age-related diseases including cancers, neurodegenerative disorders and diabetes.

    One way all mammalian cells produce energy is via aerobic respiration, in which large molecules are broken down into smaller ones, releasing energy in the process. This mainly occurs in the mitochondria the "powerhouses" of cells. Mitochondria carry their own genomes, but some of the cellular components needed for respiration are produced partly by the nucleus, so the two must coordinate their activities.

    As we age, mitochondrial function declines, which can lead to conditions such as Alzheimer's disease and diabetes. To investigate why this decline occurs, Ana Gomes at Harvard Medical School and her colleagues compared the levels of messenger RNA (mRNA) molecules that convey genetic information around a cell for the cellular components needed for respiration in the skeletal muscle of 6 and 22-month-old mice.

    They found that the level of the mRNA in the nucleus did not change much between the young and old mice, whereas those from the mitochondria appeared to decline with age.

    Similar changes were seen in mice that lacked a protein called SIRT1 high levels of which are associated with calorie restriction and an increased lifespan. These mice also had higher levels of a protein produced by the nucleus called hypoxia inducible factor (HIF-1α).

    What was going on? It appears that communication between the nucleus and the mitochondria depends on a cascade of events involving HIF-1α and SIRT1. As long as SIRT1 levels remain high and the two genomes communicate well, ageing is kept at bay. But another molecule called NAD+ keeps SIRT1 on the job; crucially, the amount of NAD+ present in the cell declines with age, though no one knows why, leading to a breakdown in communication.
    Turning back time

    The team wondered if this aspect of ageing could be reversed by increasing the amount of SIRT1 in the cells. To find out if that was possible, they injected 22-month-old mice twice daily for a week with nicotinamide mono nucleotide (NMN) a molecule known to increase levels of NAD.

    At the end of the week, markers of muscular atrophy and inflammation had dropped and the mice had even developed a different muscle type more common in younger mice. Together, these features were characteristic of 6-month-old mice.

    "We found that modulating this pathway can improve mitochondrial function and age-associated pathologies in old mice, and therefore it gives a new pathway to target that can reverse some aspects of ageing," says Gomes.

    "This paper clearly demonstrates that NAD+ production is a sort of 'Achilles' heel', [a lack of which] significantly contributes to ageing, and also that this problem can be ameliorated by boosting NAD+ production with key intermediates, such as NMN," says Shin-Ichiro Imai, at Washington University School of Medicine in St Louis, Missouri."
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